An In Vivo High-Throughput Screening Approach Targeting the Type IV Secretion System Component VirB8 Identified Inhibitors of Brucella abortus 2308 Proliferation

As bacterial pathogens develop resistance against most currently used antibiotics, novel alternatives for treatment of microbial infectious diseases are urgently needed. Targeting bacterial virulence functions in order to disarm pathogens represents a promising alternative to classical antibiotic th...

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Main Authors: Paschos, Athanasios, den Hartigh, Andreas, Smith, Mark A., Atluri, Vidya L., Sivanesan, Durga, Tsolis, Renée M., Baron, Christian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067494/
https://ncbi.nlm.nih.gov/pubmed/21173315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00993-10
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