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Fumarate hydratase inactivation in renal tumors: HIF1α, NRF2, and “cryptic targets” of transcription factors

Biallelic inactivation of fumarate hydratase (FH) causes type 2 papillary renal cell carcinoma (PRCC2), uterine fibroids, and cutaneous leimyomas, a condition known as hereditary leiomyomatosis and renal cell cancer (HLRCC). The most direct effect of FH inactivation is intracellular fumarate accumul...

詳細記述

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書誌詳細
主要な著者: Ooi, Aikseng, Furge, Kyle A.
フォーマット: Artigo
言語:Inglês
出版事項: Sun Yat-sen University Cancer Center 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777506/
https://ncbi.nlm.nih.gov/pubmed/22776233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5732/cjc.012.10102
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