Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes

Germ line mutations of the gene encoding the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) cause a hereditary cancer syndrome known as hereditary leiomyomatosis and renal cell cancer (HLRCC). HLRCC-associated tumors harbor biallelic FH inactivation that results in the accumulation of...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Kerins, Michael John, Vashisht, Ajay Amar, Liang, Benjamin Xi-Tong, Duckworth, Spencer Jordan, Praslicka, Brandon John, Wohlschlegel, James Akira, Ooi, Aikseng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440649/
https://ncbi.nlm.nih.gov/pubmed/28289076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00079-17
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