Biallelic Inactivation of Fumarate Hydratase (FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors

Germline mutations in the fumarate hydratase (FH) gene at 1q43 predispose to dominantly inherited cutaneous and uterine leiomyomas, uterine leiomyosarcoma, and papillary renal cell cancer (HLRCC syndrome). To evaluate the role of FH inactivation in sporadic tumorigenesis, we analyzed a series of 299...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Lehtonen, Rainer, Kiuru, Maija, Vanharanta, Sakari, Sjöberg, Jari, Aaltonen, Leena-Maija, Aittomäki, Kristiina, Arola, Johanna, Butzow, Ralf, Eng, Charis, Husgafvel-Pursiainen, Kirsti, Isola, Jorma, Järvinen, Heikki, Koivisto, Pasi, Mecklin, Jukka-Pekka, Peltomäki, Päivi, Salovaara, Reijo, Wasenius, Veli-Matti, Karhu, Auli, Launonen, Virpi, Nupponen, Nina N., Aaltonen, Lauri A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Investigative Pathology 2004
Onderwerpen:
Short Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602244/
https://ncbi.nlm.nih.gov/pubmed/14695314
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items