Stress-Induced Expression of a Novel Variant of Human Fumarate Hydratase (FH)

Fumarate hydratase (FH) is an enzyme of the mitochondrial tricarboxylic acid cycle (TCAC). Here we report the characterization of a novel FH variant (FHv) that contains an alternative exon 1b, thus lacking the mitochondrial signal sequence. Distinct from mitochondrial FH, FHv localized to cytosol an...

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Udgivet i:Gene Expr
Main Authors: Lehtonen, Heli J., Ylisaukko-oja, Sanna K., Kiuru, Maija, Karhu, Auli, Lehtonen, Rainer, Vanharanta, Sakari, Jalanko, Anu, Aaltonen, Lauri A., Launonen, Virpi
Format: Artigo
Sprog:Inglês
Udgivet: Cognizant Communication Corporation 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042040/
https://ncbi.nlm.nih.gov/pubmed/18257390
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