Increased risk of cancer in patients with fumarate hydratase germline mutation

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a tumour predisposition syndrome caused by heterozygous germline mutations in the fumarate hydratase (FH) gene. The condition is characterised by predisposition to benign leiomyomas of the skin and the uterus, renal cell carcinoma (RCC), and...

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Main Authors: Lehtonen, H J, Kiuru, M, Ylisaukko‐oja, S K, Salovaara, R, Herva, R, Koivisto, P A, Vierimaa, O, Aittomäki, K, Pukkala, E, Launonen, V, Aaltonen, L A
Format: Artigo
Jezik:Inglês
Izdano: BMJ Group 2006
Teme:
Short Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564537/
https://ncbi.nlm.nih.gov/pubmed/16155190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.036400
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