Increased risk of cancer in patients with fumarate hydratase germline mutation

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a tumour predisposition syndrome caused by heterozygous germline mutations in the fumarate hydratase (FH) gene. The condition is characterised by predisposition to benign leiomyomas of the skin and the uterus, renal cell carcinoma (RCC), and...

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Détails bibliographiques
Auteurs principaux: Lehtonen, H J, Kiuru, M, Ylisaukko‐oja, S K, Salovaara, R, Herva, R, Koivisto, P A, Vierimaa, O, Aittomäki, K, Pukkala, E, Launonen, V, Aaltonen, L A
Format: Artigo
Langue:Inglês
Publié: BMJ Group 2006
Sujets:
Short Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564537/
https://ncbi.nlm.nih.gov/pubmed/16155190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.036400
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