Biallelic Inactivation of Fumarate Hydratase (FH) Occurs in Nonsyndromic Uterine Leiomyomas but Is Rare in Other Tumors

Germline mutations in the fumarate hydratase (FH) gene at 1q43 predispose to dominantly inherited cutaneous and uterine leiomyomas, uterine leiomyosarcoma, and papillary renal cell cancer (HLRCC syndrome). To evaluate the role of FH inactivation in sporadic tumorigenesis, we analyzed a series of 299...

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Autors principals: Lehtonen, Rainer, Kiuru, Maija, Vanharanta, Sakari, Sjöberg, Jari, Aaltonen, Leena-Maija, Aittomäki, Kristiina, Arola, Johanna, Butzow, Ralf, Eng, Charis, Husgafvel-Pursiainen, Kirsti, Isola, Jorma, Järvinen, Heikki, Koivisto, Pasi, Mecklin, Jukka-Pekka, Peltomäki, Päivi, Salovaara, Reijo, Wasenius, Veli-Matti, Karhu, Auli, Launonen, Virpi, Nupponen, Nina N., Aaltonen, Lauri A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2004
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602244/
https://ncbi.nlm.nih.gov/pubmed/14695314
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