Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

Germline mutations of FH, the gene that encodes for the tricarboxylic acid TCA (TCA) cycle enzyme fumarate hydratase, are associated with an inherited form of cancer referred to as Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC). Individuals with HLRCC are predisposed to the development of h...

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Detalhes bibliográficos
Main Authors: Sudarshan, Sunil, Shanmugasundaram, Karthigayan, Naylor, Susan L., Lin, Shu, Livi, Carolina B., O'Neill, Christine F., Parekh, Dipen J., Yeh, I-Tien, Sun, Lu-Zhe, Block, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114862/
https://ncbi.nlm.nih.gov/pubmed/21695080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021037
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