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Pharmacodynamic modeling of cell cycle and apoptotic effects of gemcitabine on pancreatic adenocarcinoma cells
PURPOSE: The standard of care for treating patients with pancreatic adenocarcinomas includes gemcitabine (2′,2′-difluorodeoxycytidine). Gemcitabine primarily elicits its response by stalling the DNA replication forks of cells in the S phase of the cell cycle. To provide a quantitative framework for...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3777243/ https://ncbi.nlm.nih.gov/pubmed/23835677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2226-6 |
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