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Physiologically-based pharmacokinetic and pharmacodynamic models for gemcitabine and birinapant in pancreatic cancer xenografts

The anticancer effects of combined gemcitabine and birinapant were demonstrated as synergistic in PANC-1 cells in vitro. In this study, pharmacokinetic information derived from experiments and the literature was utilized to develop full physiologically-based pharmacokinetic (PBPK) models that charac...

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Bibliografiska uppgifter
I publikationen:J Pharmacokinet Pharmacodyn
Huvudupphovsmän: Zhu, Xu, Trueman, Sheryl, Straubinger, Robert M., Jusko, William J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160358/
https://ncbi.nlm.nih.gov/pubmed/30069744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-018-9603-z
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