PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activation

BACKGROUND: Preclinical studies have shown that PTEN loss enhances sensitivity to mammalian target of Rapamycin (mTOR) inhibitors because of facilitated PI3K (phosphatidylinositol-3 kinase)/Akt activation and consecutive stimulation of the mTOR pathway. In patients with advanced transitional cell ca...

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Autori principali: Seront, E, Pinto, A, Bouzin, C, Bertrand, L, Machiels, J-P, Feron, O
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777009/
https://ncbi.nlm.nih.gov/pubmed/23989949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.505
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