Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells

The PI3K/AKT/mTOR signaling pathway is constitutively active in PTEN-deficient cancer cells, and its targeted inhibition has significant anti-tumor effects. However, the efficacy of targeted therapies is often limited due to drug resistance. The relevant signaling pathways in PTEN-deficient cancer c...

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Udgivet i:Oncogenesis
Main Authors: Wang, Jian, Lv, Xiaoye, Guo, Xiutian, Dong, Yanbo, Peng, Peipei, Huang, Fang, Wang, Peng, Zhang, Haoqian, Zhou, Jianguang, Wang, Youliang, Wei, Bo, Shang, Zeng-Fu, Li, Shanhu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801611/
https://ncbi.nlm.nih.gov/pubmed/33431808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00292-w
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