Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent form of dementia. The amyloid beta (Aβ) peptide is the predominant candidate aetiological agent and is generated through the sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by beta (β) and gamma (γ) secretases. Since the cell...

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Autors principals: Jovanovic, Katarina, Gonsalves, Danielle, Da Costa Dias, Bianca, Moodley, Kiashanee, Reusch, Uwe, Knackmuss, Stefan, Penny, Clement, Weinberg, Marc S., Little, Melvyn, Weiss, Stefan F. T.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776966/
https://ncbi.nlm.nih.gov/pubmed/24048412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02699
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