Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent form of dementia. The amyloid beta (Aβ) peptide is the predominant candidate aetiological agent and is generated through the sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by beta (β) and gamma (γ) secretases. Since the cell...

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Autori principali: Jovanovic, Katarina, Gonsalves, Danielle, Da Costa Dias, Bianca, Moodley, Kiashanee, Reusch, Uwe, Knackmuss, Stefan, Penny, Clement, Weinberg, Marc S., Little, Melvyn, Weiss, Stefan F. T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776966/
https://ncbi.nlm.nih.gov/pubmed/24048412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02699
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