Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent form of dementia. The amyloid beta (Aβ) peptide is the predominant candidate aetiological agent and is generated through the sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by beta (β) and gamma (γ) secretases. Since the cell...

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Main Authors: Jovanovic, Katarina, Gonsalves, Danielle, Da Costa Dias, Bianca, Moodley, Kiashanee, Reusch, Uwe, Knackmuss, Stefan, Penny, Clement, Weinberg, Marc S., Little, Melvyn, Weiss, Stefan F. T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776966/
https://ncbi.nlm.nih.gov/pubmed/24048412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02699
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