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Genetic Deficiency of Anti-Aging Gene Klotho Exacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice

Klotho is a recently discovered anti-aging gene and is primarily expressed in kidneys. In humans, the klotho level decreases with age whereas the prevalence of chronic kidney disease (CKD) increases with age. Diabetic nephropathy is the most common form of CKD, which leads to end-stage renal disease...

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Main Authors: Lin, Yi, Kuro-o, Makoto, Sun, Zhongjie
פורמט: Artigo
שפה:Inglês
יצא לאור: Endocrine Society 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776873/
https://ncbi.nlm.nih.gov/pubmed/23928372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1053
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