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TP53-independent Function of miR-34a via HDAC1 and p21(CIP1/WAF1)
The tumor suppressor, microRNA-34 (miR-34), a transcriptional target of TP53, functions in a positive feedback loop to activate TP53. Although miR-34 can inhibit cancer cells carrying TP53 mutations, this feedback to TP53 may be a prerequisite for full miR-34 function and may restrict its therapeuti...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3776635/ https://ncbi.nlm.nih.gov/pubmed/23836017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.148 |
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