By recruiting HDAC1, MORC2 suppresses p21Waf1/Cip1 in gastric cancer

Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediate...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Zhang, Qing, Song, Yanyan, Chen, Wei, Wang, Xiaohui, Miao, Zhifeng, Cao, Liu, Li, Feng, Wang, Guiling
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599282/
https://ncbi.nlm.nih.gov/pubmed/26098774
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