Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required for centriole assembly, but it is unclear how...

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Detalhes bibliográficos
Main Authors: Cottee, Matthew A, Muschalik, Nadine, Wong, Yao Liang, Johnson, Christopher M, Johnson, Steven, Andreeva, Antonina, Oegema, Karen, Lea, Susan M, Raff, Jordan W, van Breugel, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776556/
https://ncbi.nlm.nih.gov/pubmed/24052813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01071
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