The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary microcephaly (MCPH). Here, we show that human STIL has an asymmetric localization to the daughter centriole and is required for procentriole formation. STIL leve...

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Detalhes bibliográficos
Main Authors: Tang, Chieh-Ju C, Lin, Shin-Yi, Hsu, Wen-Bin, Lin, Yi-Nan, Wu, Chien-Ting, Lin, Yu-Chih, Chang, Ching-Wen, Wu, Kuo-Sheng, Tang, Tang K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243611/
https://ncbi.nlm.nih.gov/pubmed/22020124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.378
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