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The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation
Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary microcephaly (MCPH). Here, we show that human STIL has an asymmetric localization to the daughter centriole and is required for procentriole formation. STIL leve...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243611/ https://ncbi.nlm.nih.gov/pubmed/22020124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.378 |
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