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Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging
TRAIL holds promise as an anti-cancer therapeutic but induces apoptosis in only a subset of tumor cell types. Moreover, many cancers that are responsive to TRAIL-mediated death exhibit partial sensitivity, with only a fraction of cells dying in response to treatment. Even within clonal populations o...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3775495/ https://ncbi.nlm.nih.gov/pubmed/23735516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1088/1478-3975/10/3/035002 |
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