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Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis

Stochastic fluctuations in gene expression give rise to cell-to-cell variability in protein levels which can potentially cause variability in cellular phenotype. For TRAIL (TNF-related apoptosis-inducing ligand) variability manifests itself as dramatic differences in the time between ligand exposure...

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Detalhes bibliográficos
Main Authors: Gaudet, Suzanne, Spencer, Sabrina L., Chen, William W., Sorger, Peter K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343095/
https://ncbi.nlm.nih.gov/pubmed/22570596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002482
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