Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils

Biliary obstruction is a common clinical problem that is associated with intrahepatic inflammation and impaired immunity. PD-1 is well known to mediate T cell dysfunction but has been reported to promote and attenuate acute inflammation in various injury models. With the use of a well-established mu...

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Main Authors: Licata, Lauren A., Nguyen, Cang T., Burga, Rachel A., Falanga, Vincent, Espat, N. Joseph, Ayala, Alfred, Thorn, Mitchell, Junghans, Richard P., Katz, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2013
Assuntos:
Inflammation, Extracellular Mediators, & Effector Molecules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774842/
https://ncbi.nlm.nih.gov/pubmed/23883516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0313137
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