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Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

The thiazolidinedione class of insulin-sensitizing, antidiabetic drugs interacts with peroxisome proliferator–activated receptor γ (PPAR-γ). To gain insight into the role of this nuclear receptor in insulin resistance and diabetes, we conducted metabolic studies in the PPAR-γ gene knockout mouse mod...

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Udgivet i:J Clin Invest
Principais autores: Miles, Philip D.G., Barak, Yaacov, He, Weiman, Evans, Ronald M., Olefsky, Jerrold M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC377448/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10675354/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8538
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