Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

The thiazolidinedione class of insulin-sensitizing, antidiabetic drugs interacts with peroxisome proliferator–activated receptor γ (PPAR-γ). To gain insight into the role of this nuclear receptor in insulin resistance and diabetes, we conducted metabolic studies in the PPAR-γ gene knockout mouse mod...

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Publié dans:	J Clin Invest
Auteurs principaux:	Miles, Philip D.G., Barak, Yaacov, He, Weiman, Evans, Ronald M., Olefsky, Jerrold M.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 2000
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC377448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10675354/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8538
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