PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression

The mortality rate for acute lung injury (ALI) is reported to be between 35–40%, and there are very few treatment strategies that improve the death rate from this condition. Previous studies have suggested that signaling through the prostaglandin (PG) I(2) receptor may protect against bleomycin-indu...

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Autori principali: Zhou, Weisong, Dowell, Dustin R., Geraci, Mark W., Blackwell, Timothy S., Collins, Robert D., Polosukhin, Vasiliy V., Lawson, William E., Wu, Pingsheng, Sussan, Thomas, Biswal, Shyam, Goleniewska, Kasia, O'Neal, Jamye, Newcomb, Dawn C., Toki, Shinji, Morrow, Jason D., Peebles, R. Stokes
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774255/
https://ncbi.nlm.nih.gov/pubmed/21764988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00224.2010
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