COX inhibition abrogates aeroallergen-induced immune tolerance by suppressing PGI(2) IP signaling

BACKGROUND: The prevalence of allergic diseases doubled in developed countries in the last several decades. Cyclooxygenase (COX) inhibiting drugs augmented allergic diseases in mice by increasing allergic sensitization and memory immune responses. However, whether COX inhibition can promote allergic...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Zhou, Weisong, Goleniewska, Kasia, Zhang, Jian, Dulek, Daniel E., Toki, Shinji, Lotz, Matthew T., Newcomb, Dawn C., Boswell, Madison G., Polosukhin, Vasiliy V., Milne, Ginger L., Wu, Pingsheng, Moore, Martin L., FitzGerald, Garret A., Peebles, R. Stokes
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358822/
https://ncbi.nlm.nih.gov/pubmed/25042746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.06.004
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