COX inhibition abrogates aeroallergen-induced immune tolerance by suppressing PGI(2) IP signaling

BACKGROUND: The prevalence of allergic diseases doubled in developed countries in the last several decades. Cyclooxygenase (COX) inhibiting drugs augmented allergic diseases in mice by increasing allergic sensitization and memory immune responses. However, whether COX inhibition can promote allergic...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Zhou, Weisong, Goleniewska, Kasia, Zhang, Jian, Dulek, Daniel E., Toki, Shinji, Lotz, Matthew T., Newcomb, Dawn C., Boswell, Madison G., Polosukhin, Vasiliy V., Milne, Ginger L., Wu, Pingsheng, Moore, Martin L., FitzGerald, Garret A., Peebles, R. Stokes
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358822/
https://ncbi.nlm.nih.gov/pubmed/25042746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.06.004
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