Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice

The matrix metalloproteinases (MMPs) play a pivotal role in adverse left ventricular (LV) myocardial remodeling. The transmembrane protein extracellular MMP inducer (EMMPRIN) causes increased MMP expression in vitro, and elevated levels occur in patients with LV failure. However, the direct conseque...

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Autori principali: Zavadzkas, Juozas A., Plyler, Rebecca A., Bouges, Shenikqua, Koval, Christine N., Rivers, William T., Beck, Christy U., Chang, Eileen I., Stroud, Robert E., Mukherjee, Rupak, Spinale, Francis G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774181/
https://ncbi.nlm.nih.gov/pubmed/18689500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00346.2008
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