Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice

The matrix metalloproteinases (MMPs) play a pivotal role in adverse left ventricular (LV) myocardial remodeling. The transmembrane protein extracellular MMP inducer (EMMPRIN) causes increased MMP expression in vitro, and elevated levels occur in patients with LV failure. However, the direct conseque...

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Hlavní autoři: Zavadzkas, Juozas A., Plyler, Rebecca A., Bouges, Shenikqua, Koval, Christine N., Rivers, William T., Beck, Christy U., Chang, Eileen I., Stroud, Robert E., Mukherjee, Rupak, Spinale, Francis G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774181/
https://ncbi.nlm.nih.gov/pubmed/18689500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00346.2008
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