Cardiac Restricted Over-Expression of Membrane Type-1 Matrix Metalloproteinase in Mice: Effects on Myocardial Remodeling with Aging

BACKGROUND: The direct consequences of a persistently increased myocardial expression of the unique matrix metalloproteinase (MMP), membrane type-1 (MT1-MMP) on myocardial remodeling remained unexplored. METHODS/RESULTS: Cardiac restricted MT1-MMPexp was constructed in mice using the full length hum...

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Main Authors: Spinale, Francis G., Patricia Escobar, G., Mukherjee, Rupak, Zavadzkas, Juozas A., Saunders, Stuart M., Jeffords, Laura B., Leone, Allyson M., Beck, Christy, Bouges, Shenikqua, Stroud, Robert E.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743030/
https://ncbi.nlm.nih.gov/pubmed/19808359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.108.844845
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