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Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues
A series of 1,5-disubstituted tetrazole-tethered combretastatin analogues with extended hydrogen-bond donors at the ortho-positions of the aryl A and B rings were developed and evaluated for their antitubulin and antiproliferative activity. We wanted to test whether intramolecular hydrogen-bonding u...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774141/ https://ncbi.nlm.nih.gov/pubmed/23809851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.004 |
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