Synthesis and Evaluation of 1,5-Disubstituted Tetrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative and Antitumor Activity

[Image: see text] Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. Two series of 1,5-diaryl substituted 1,2,3,4-tetrazoles were concisely synthesized, using a palladium-catalyzed cross-coupling reaction, and identified as potent antiproli...

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Detalhes bibliográficos
Main Authors: Romagnoli, Romeo, Baraldi, Pier Giovanni, Salvador, Maria Kimatrai, Preti, Delia, Tabrizi, Mojgan Aghazadeh, Brancale, Andrea, Fu, Xian-Hua, Li, Jun, Zhang, Su-Zhan, Hamel, Ernest, Bortolozzi, Roberta, Basso, Giuseppe, Viola, Giampietro
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266058/
https://ncbi.nlm.nih.gov/pubmed/22136312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2013979
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