Synthesis and Antiproliferative Effects of 5,6-Disubstituted Pyridazin-3(2H)-ones Designed as Conformationally Constrained Combretastatin A-4 Analogues

Novel 5,6-disubstituted pyridazin-3(2H)-one derivatives were designed and synthesized as combretastatin A-4 analogues. Our objective was to overcome the spontaneous cis to trans isomerization of the compound. We therefore replaced the cis-double bond with a pyridazine ring. The antiproliferative act...

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Hauptverfasser: Elagawany, Mohamed, Schmitt, Martine, Ghiaty, Adel, El-Etrawy, A. Sh., Ibrahim, Mohamed A., Bihel, Frédéric, Sbardelotto, Aline Borba, Pessoa, Cláudia, Nguyen, Tam Luong, Hamel, Ernest, Bourguignon, Jean Jacques
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815669/
https://ncbi.nlm.nih.gov/pubmed/23574386
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