Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response

SKN-1/Nrf plays multiple essential roles in development and cellular homeostasis. We demonstrate that SKN-1 executes a specific and appropriate transcriptional response to changes in available nutrients, leading to metabolic adaptation. We isolated gain-of-function (gf) alleles of skn-1, affecting a...

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Auteurs principaux: Paek, Jennifer, Lo, Jacqueline Y., Narasimhan, Sri Devi, Nguyen, Tammy N., Glover-Cutter, Kira, Robida-Stubbs, Stacey, Suzuki, Takafumi, Yamamoto, Masayuki, Blackwell, T. Keith, Curran, Sean P.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774140/
https://ncbi.nlm.nih.gov/pubmed/23040073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.09.007
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