Intestinal CYP3A4 and Midazolam Disposition in vivo Associate with VDR Polymorphisms and Show Seasonal Variation

Vitamin D, whose levels vary seasonally with sunlight, is activated to 1α,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression. We genotyped VDR polymorphisms and determined their associations with intestinal CYP3A4 and with mi...

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Detalhes bibliográficos
Main Authors: Thirumaran, Ranjit K., Lamba, Jatinder K., Kim, Richard B., Urquhart, Brad L., Gregor, Jamie C., Chande, Nilesh, Fan, Yiping, Qi, An, Cheng, Cheng, Thummel, Kenneth E., Hall, Stephen D., Schuetz, Erin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774043/
https://ncbi.nlm.nih.gov/pubmed/22484315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.03.017
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