Exploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians

AIM: Genetic polymorphisms have the potential to influence drug metabolism and vary among ethnic groups. This study evaluated the correlation of genetic polymorphisms with nevirapine pharmacokinetics exposure in Malawians. MATERIALS & METHODS: CYP450 2B6, 2D6, 3A4 and 3A5, ABCB1 and constitutive...

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Detalhes bibliográficos
Main Authors: Brown, Kevin C, Hosseinipour, Mina C, Hoskins, Janelle M, Thirumaran, Ranjit K, Tien, Hsiao-Chuan, Weigel, Ralf, Tauzie, Jean, Shumba, Ida, Lamba, Jatinder K, Schuetz, Erin G, McLeod, Howard L, Kashuba, Angela DM, Corbett, Amanda H
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292264/
https://ncbi.nlm.nih.gov/pubmed/22111602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.11.132
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