Relaxin Suppresses Atrial Fibrillation by Reversing Fibrosis and Myocyte Hypertrophy, and Increasing Conduction Velocity and Sodium Current in Spontaneously Hypertensive Rat Hearts

RATIONALE: Atrial fibrillation (AF) contributes significantly to morbidity and mortality in elderly and hypertensive patients and has been correlated to enhanced atrial fibrosis. Despite a lack of direct evidence that fibrosis causes AF, reversal of fibrosis is considered as a plausible therapy. OBJ...

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Autori principali: Parikh, Ashish, Patel, Divyang, McTiernan, Charles F., Xiang, Wenyu, Haney, Jamie, Yang, Lei, Lin, Bo, Kaplan, Aaron D., Bett, Glenna C.L., Rasmusson, Randall L., Shroff, Sanjeev G., Schwartzman, David, Salama, Guy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774019/
https://ncbi.nlm.nih.gov/pubmed/23748429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.301646
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