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Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α-Hemolysin Ion Channel

Nanopore technology holds high potential for next-generation DNA sequencing. This method operates by drawing an individual single-stranded DNA molecule through a nanoscale pore while monitoring the current deflections that occur as the DNA passes through. Individual current levels for the four DNA n...

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Autors principals: Wolna, Anna H., Fleming, Aaron M., An, Na, He, Lidong, White, Henry S., Burrows, Cynthia J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773884/
https://ncbi.nlm.nih.gov/pubmed/24052667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijch.201300022
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