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Integration of mTOR and estrogen–ERK2 signaling in lymphangioleiomyomatosis pathogenesis
Lymphangioleiomyomatosis (LAM) is a destructive lung disease of women associated with the metastasis of tuberin-null cells with hyperactive mammalian target of rapamycin complex 1 (mTORC1) activity. Clinical trials with the mTORC1 inhibitor rapamycin have revealed partial efficacy but are not curati...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773757/ https://ncbi.nlm.nih.gov/pubmed/23983265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309110110 |
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