Integration of mTOR and estrogen–ERK2 signaling in lymphangioleiomyomatosis pathogenesis

Lymphangioleiomyomatosis (LAM) is a destructive lung disease of women associated with the metastasis of tuberin-null cells with hyperactive mammalian target of rapamycin complex 1 (mTORC1) activity. Clinical trials with the mTORC1 inhibitor rapamycin have revealed partial efficacy but are not curati...

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Bibliographic Details
Main Authors: Gu, Xiaoxiao, Yu, Jane J., Ilter, Didem, Blenis, Nickolas, Henske, Elizabeth Petri, Blenis, John
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773757/
https://ncbi.nlm.nih.gov/pubmed/23983265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309110110
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