Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases

The CXCR4/CXCL12 axis plays a role in cancer metastases, stem cell mobilization and chemosensitization. Proof of concept for efficient CXCR4 inhibition has been demonstrated in stem cell mobilization prior to autologous transplantation in hematological malignancies. Nevertheless CXCR4 inhibitors sui...

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Main Authors: Portella, Luigi, Vitale, Rosamaria, De Luca, Stefania, D’Alterio, Crescenzo, Ieranò, Caterina, Napolitano, Maria, Riccio, Anna, Polimeno, Maria Neve, Monfregola, Luca, Barbieri, Antonio, Luciano, Antonio, Ciarmiello, Andrea, Arra, Claudio, Castello, Giuseppe, Amodeo, Pietro, Scala, Stefania
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772838/
https://ncbi.nlm.nih.gov/pubmed/24058588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074548
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