Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1

BACKGROUND: Inefficient T-cell access to the tumor microenvironment (TME) is among the causes of tumor immune-resistance. Previous evidence demonstrated that targeting CXCR4 improves anti-PD-1/PD-L1 efficacy reshaping TME. To evaluate the role of newly developed CXCR4 antagonists (PCT/IB2011/000120/...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: D’Alterio, Crescenzo, Buoncervello, Maria, Ieranò, Caterina, Napolitano, Maria, Portella, Luigi, Rea, Giuseppina, Barbieri, Antonio, Luciano, Antonio, Scognamiglio, Giosuè, Tatangelo, Fabiana, Anniciello, Anna Maria, Monaco, Mario, Cavalcanti, Ernesta, Maiolino, Piera, Romagnoli, Giulia, Arra, Claudio, Botti, Gerardo, Gabriele, Lucia, Scala, Stefania
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819555/
https://ncbi.nlm.nih.gov/pubmed/31661001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1420-8
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