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Mitochondrial DNA Ligase Is Dispensable for the Viability of Cultured Cells but Essential for mtDNA Maintenance

Multiple lines of evidence support the notion that DNA ligase III (LIG3), the only DNA ligase found in mitochondria, is essential for viability in both whole organisms and in cultured cells. Previous attempts to generate cells devoid of mitochondrial DNA ligase failed. Here, we report, for the first...

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Библиографические подробности
Главные авторы: Shokolenko, Inna N., Fayzulin, Rafik Z., Katyal, Sachin, McKinnon, Peter J., Wilson, Glenn L., Alexeyev, Mikhail F.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772206/
https://ncbi.nlm.nih.gov/pubmed/23884459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.472977
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