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Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number

Due to the essential role played by mitochondrial DNA (mtDNA) in cellular physiology and bioenergetics, methods for establishing cell lines with altered mtDNA content are of considerable interest. Here, we report evidence for the existence in mammalian cells of a novel, low- efficiency, presequence-...

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Publicado en:PLoS One
Autores principales: Spadafora, Domenico, Kozhukhar, Natalia, Alexeyev, Mikhail F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816344/
https://ncbi.nlm.nih.gov/pubmed/27031233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152705
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