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Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number

Due to the essential role played by mitochondrial DNA (mtDNA) in cellular physiology and bioenergetics, methods for establishing cell lines with altered mtDNA content are of considerable interest. Here, we report evidence for the existence in mammalian cells of a novel, low- efficiency, presequence-...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Spadafora, Domenico, Kozhukhar, Natalia, Alexeyev, Mikhail F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816344/
https://ncbi.nlm.nih.gov/pubmed/27031233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152705
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