Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines

Human bispecific antibodies have great potential for the treatment of human diseases. Although human IgG1 bispecific antibodies have been generated, few attempts have been reported in the scientific literature that extend bispecific antibodies to other human antibody isotypes. In this paper, we repo...

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Autors principals: Spiess, Christoph, Bevers, Jack, Jackman, Janet, Chiang, Nancy, Nakamura, Gerald, Dillon, Michael, Liu, Hongbin, Molina, Patricia, Elliott, J. Michael, Shatz, Whitney, Scheer, Justin M., Giese, Glen, Persson, Josefine, Zhang, Yin, Dennis, Mark S., Giulianotti, James, Gupta, Prateek, Reilly, Dorothea, Palma, Enzo, Wang, Jianyong, Stefanich, Eric, Scheerens, Heleen, Fuh, Germaine, Wu, Lawren C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772205/
https://ncbi.nlm.nih.gov/pubmed/23880771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480483
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