Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines

Human bispecific antibodies have great potential for the treatment of human diseases. Although human IgG1 bispecific antibodies have been generated, few attempts have been reported in the scientific literature that extend bispecific antibodies to other human antibody isotypes. In this paper, we repo...

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Main Authors: Spiess, Christoph, Bevers, Jack, Jackman, Janet, Chiang, Nancy, Nakamura, Gerald, Dillon, Michael, Liu, Hongbin, Molina, Patricia, Elliott, J. Michael, Shatz, Whitney, Scheer, Justin M., Giese, Glen, Persson, Josefine, Zhang, Yin, Dennis, Mark S., Giulianotti, James, Gupta, Prateek, Reilly, Dorothea, Palma, Enzo, Wang, Jianyong, Stefanich, Eric, Scheerens, Heleen, Fuh, Germaine, Wu, Lawren C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772205/
https://ncbi.nlm.nih.gov/pubmed/23880771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480483
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