Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

Chronic saturated fatty acid exposure causes β-cell apoptosis and, thus, contributes to type 2 diabetes. Although endoplasmic reticulum (ER) stress and reduced ER-to-Golgi protein trafficking have been implicated, the exact mechanisms whereby saturated fatty acids trigger β-cell death remain elusive...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Boslem, Ebru, Weir, Jacquelyn M., MacIntosh, Gemma, Sue, Nancy, Cantley, James, Meikle, Peter J., Biden, Trevor J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772204/
https://ncbi.nlm.nih.gov/pubmed/23897822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489310
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