Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells

BACKGROUND: Chronic exposure of pancreatic β-cells to excess free fatty acids is thought to contribute to type 2 diabetes pathogenesis in obesity by impairing β-cell function and even leading to apoptosis. In β-cells, lipid droplet-associated protein perilipin 5 (PLIN5) has been shown to enhance ins...

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Detalhes bibliográficos
Publicado no:Nutr Metab (Lond)
Main Authors: Zhu, Yunxia, Zhang, Xiaoyan, Zhang, Li, Zhang, Mingliang, Li, Ling, Luo, Deng, Zhong, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668071/
https://ncbi.nlm.nih.gov/pubmed/31384284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-019-0375-2
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