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Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells
BACKGROUND: Chronic exposure of pancreatic β-cells to excess free fatty acids is thought to contribute to type 2 diabetes pathogenesis in obesity by impairing β-cell function and even leading to apoptosis. In β-cells, lipid droplet-associated protein perilipin 5 (PLIN5) has been shown to enhance ins...
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| Publicat a: | Nutr Metab (Lond) |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6668071/ https://ncbi.nlm.nih.gov/pubmed/31384284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-019-0375-2 |
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