A Neutralizing Monoclonal Antibody Targeting the Acid-Sensitive Region in Chikungunya Virus E2 Protects from Disease

The mosquito-borne alphavirus, chikungunya virus (CHIKV), has recently reemerged, producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute and chronic rheumatic disease. There are currently no licensed vaccines for CHIKV and current anti-inflammatory drug tr...

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Hauptverfasser: Selvarajah, Suganya, Sexton, Nicole R., Kahle, Kristen M., Fong, Rachel H., Mattia, Kimberly-Anne, Gardner, Joy, Lu, Kai, Liss, Nathan M., Salvador, Beatriz, Tucker, David F., Barnes, Trevor, Mabila, Manu, Zhou, Xiangdong, Rossini, Giada, Rucker, Joseph B., Sanders, David Avram, Suhrbier, Andreas, Sambri, Vittorio, Michault, Alain, Muench, Marcus O., Doranz, Benjamin J., Simmons, Graham
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772074/
https://ncbi.nlm.nih.gov/pubmed/24069479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002423
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