Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies

Cocktails of monoclonal antibodies (MAbs) that target the surface glycoprotein (GP) of Ebola virus (EBOV) are effective in nonhuman primate models and have been used under emergency compassionate-treatment protocols in human patients. However, the amino acids that form the detailed binding epitopes...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Davidson, Edgar, Bryan, Christopher, Fong, Rachel H., Barnes, Trevor, Pfaff, Jennifer M., Mabila, Manu, Rucker, Joseph B., Doranz, Benjamin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621129/
https://ncbi.nlm.nih.gov/pubmed/26311869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01490-15
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